A Non-Invasive 3D Gait Analysis Framework for Quantifying Psychomotor Retardation in Major Depressive Disorder

Predicting the status of Major Depressive Disorder (MDD) from objective, non-invasive methods is an active research field. Yet, extracting automatically objective, interpretable features for a detailed analysis of the patient state remains largely unexplored. Among MDD's symptoms, Psychomotor retardation (PMR) is a core item, yet its clinical assessment remains largely subjective. While 3D motion capture offers an objective alternative, its reliance on specialized hardware often precludes routine clinical use. In this paper, we propose a non-invasive computational framework that transforms monocular RGB video into clinically relevant 3D gait kinematics. Our pipeline uses Gravity-View Coordinates along with a novel trajectory-correction algorithm that leverages the closed-loop topology of our adapted Timed Up and Go (TUG) protocol to mitigate monocular depth errors. This novel pipeline enables the extraction of 297 explicit gait biomechanical biomarkers from a single camera capture. To address the challenges of small clinical datasets, we introduce a stability-based machine learning framework that identifies robust motor signatures while preventing overfitting. Validated on the CALYPSO dataset, our method achieves an 83.3% accuracy in detecting PMR and explains 64% of the variance in overall depression severity (R^2=0.64). Notably, our study reveals a strong link between reduced ankle propulsion and restricted pelvic mobility to the depressive motor phenotype. These results demonstrate that physical movement serves as a robust proxy for the cognitive state, offering a transparent and scalable tool for the objective monitoring of depression in standard clinical environments.

Wearable-Derived Behavioral and Physiological Biomarkers for Classifying Unipolar and Bipolar Depression Severity

Depression is a complex mental disorder characterized by a diverse range of observable and measurable indicators that go beyond traditional subjective assessments. Recent research has increasingly focused on objective, passive, and continuous monitoring using wearable devices to gain more precise insights into the physiological and behavioral aspects of depression. However, most existing studies primarily distinguish between healthy and depressed individuals, adopting a binary classification that fails to capture the heterogeneity of depressive disorders. In this study, we leverage wearable devices to predict depression subtypes-specifically unipolar and bipolar depression-aiming to identify distinctive biomarkers that could enhance diagnostic precision and support personalized treatment strategies. To this end, we introduce the CALYPSO dataset, designed for non-invasive detection of depression subtypes and symptomatology through physiological and behavioral signals, including blood volume pulse, electrodermal activity, body temperature, and three-axis acceleration. Additionally, we establish a benchmark on the dataset using well-known features and standard machine learning methods. Preliminary results indicate that features related to physical activity, extracted from accelerometer data, are the most effective in distinguishing between unipolar and bipolar depression, achieving an accuracy of $96.77\%$. Temperature-based features also showed high discriminative power, reaching an accuracy of $93.55\%$. These findings highlight the potential of physiological and behavioral monitoring for improving the classification of depressive subtypes, paving the way for more tailored clinical interventions.

Measuring Anxiety Levels with Head Motion Patterns in Severe Depression Population

Depression and anxiety are prevalent mental health disorders that frequently cooccur, with anxiety significantly influencing both the manifestation and treatment of depression. An accurate assessment of anxiety levels in individuals with depression is crucial to develop effective and personalized treatment plans. This study proposes a new noninvasive method for quantifying anxiety severity by analyzing head movements -specifically speed, acceleration, and angular displacement - during video-recorded interviews with patients suffering from severe depression. Using data from a new CALYPSO Depression Dataset, we extracted head motion characteristics and applied regression analysis to predict clinically evaluated anxiety levels. Our results demonstrate a high level of precision, achieving a mean absolute error (MAE) of 0.35 in predicting the severity of psychological anxiety based on head movement patterns. This indicates that our approach can enhance the understanding of anxiety's role in depression and assist psychiatrists in refining treatment strategies for individuals.