Longitudinal Ensemble Integration for sequential classification with multimodal data

Effectively modeling multimodal longitudinal data is a pressing need in various application areas, especially biomedicine. Despite this, few approaches exist in the literature for this problem, with most not adequately taking into account the multimodality of the data. In this study, we developed multiple configurations of a novel multimodal and longitudinal learning framework, Longitudinal Ensemble Integration (LEI), for sequential classification. We evaluated LEI's performance, and compared it against existing approaches, for the early detection of dementia, which is among the most studied multimodal sequential classification tasks. LEI outperformed these approaches due to its use of intermediate base predictions arising from the individual data modalities, which enabled their better integration over time. LEI's design also enabled the identification of features that were consistently important across time for the effective prediction of dementia-related diagnoses. Overall, our work demonstrates the potential of LEI for sequential classification from longitudinal multimodal data.

Theoretically informed selection of latent activation in autoencoder based recommender systems

Autoencoders may lend themselves to the design of more accurate and computationally efficient recommender systems by distilling sparse high-dimensional data into dense lower-dimensional latent representations. However, designing these systems remains challenging due to the lack of theoretical guidance. This work addresses this by identifying three key mathematical properties that the encoder in an autoencoder should exhibit to improve recommendation accuracy: (1) dimensionality reduction, (2) preservation of similarity ordering in dot product comparisons, and (3) preservation of non-zero vectors. Through theoretical analysis, we demonstrate that common activation functions, such as ReLU and tanh, cannot fulfill these properties jointly within a generalizable framework. In contrast, sigmoid-like activations emerge as suitable choices for latent activations. This theoretically informed approach offers a more systematic method for hyperparameter selection, enhancing the efficiency of model design.