Multi-Classification using One-versus-One Deep Learning Strategy with Joint Probability Estimates

The One-versus-One (OvO) strategy is an approach of multi-classification models which focuses on training binary classifiers between each pair of classes. While the OvO strategy takes advantage of balanced training data, the classification accuracy is usually hindered by the voting mechanism to combine all binary classifiers. In this paper, a novel OvO multi-classification model incorporating a joint probability measure is proposed under the deep learning framework. In the proposed model, a two-stage algorithm is developed to estimate the class probability from the pairwise binary classifiers. Given the binary classifiers, the pairwise probability estimate is calibrated by a distance measure on the separating feature hyperplane. From that, the class probability of the subject is estimated by solving a joint probability-based distance minimization problem. Numerical experiments in different applications show that the proposed model achieves generally higher classification accuracy than other state-of-the-art models.

QC-SPHRAM: Quasi-conformal Spherical Harmonics Based Geometric Distortions on Hippocampal Surfaces for Early Detection of the Alzheimer's Disease

We propose a disease classification model, called the QC-SPHARM, for the early detection of the Alzheimer's Disease (AD). The proposed QC-SPHARM can distinguish between normal control (NC) subjects and AD patients, as well as between amnestic mild cognitive impairment (aMCI) patients having high possibility progressing into AD and those who do not. Using the spherical harmonics (SPHARM) based registration, hippocampal surfaces segmented from the ADNI data are individually registered to a template surface constructed from the NC subjects using SPHARM. Local geometric distortions of the deformation from the template surface to each subject are quantified in terms of conformality distortions and curvatures distortions. The measurements are combined with the spherical harmonics coefficients and the total volume change of the subject from the template. Afterwards, a t-test based feature selection method incorporating the bagging strategy is applied to extract those local regions having high discriminating power of the two classes. The disease diagnosis machine can therefore be built using the data under the Support Vector Machine (SVM) setting. Using 110 NC subjects and 110 AD patients from the ADNI database, the proposed algorithm achieves 85:2% testing accuracy on 80 random samples as testing subjects, with the incorporation of surface geometry in the classification machine. Using 20 aMCI patients who has advanced to AD during a two-year period and another 20 aMCI patients who remain non-AD for the next two years, the algorithm achieves 81:2% accuracy using 10 randomly picked subjects as testing data. Our proposed method is 6%-15% better than other classification models without the incorporation of surface geometry. The results demonstrate the advantages of using local geometric distortions as the discriminating criterion for early AD diagnosis.