Abstract:The COVID-19 Infodemic had an unprecedented impact on health behaviors and outcomes at a global scale. While many studies have focused on a qualitative and quantitative understanding of misinformation, including sentiment analysis, there is a gap in understanding the emotion-carriers of misinformation and their differences across geographies. In this study, we characterized emotion carriers and their impact on vaccination rates in India and the United States. A manually labelled dataset was created from 2.3 million tweets and collated with three publicly available datasets (CoAID, AntiVax, CMU) to train deep learning models for misinformation classification. Misinformation labelled tweets were further analyzed for behavioral aspects by leveraging Plutchik Transformers to determine the emotion for each tweet. Time series analysis was conducted to study the impact of misinformation on spatial and temporal characteristics. Further, categorical classification was performed using transformer models to assign categories for the misinformation tweets. Word2Vec+BiLSTM was the best model for misinformation classification, with an F1-score of 0.92. The US had the highest proportion of misinformation tweets (58.02%), followed by the UK (10.38%) and India (7.33%). Disgust, anticipation, and anger were associated with an increased prevalence of misinformation tweets. Disgust was the predominant emotion associated with misinformation tweets in the US, while anticipation was the predominant emotion in India. For India, the misinformation rate exhibited a lead relationship with vaccination, while in the US it lagged behind vaccination. Our study deciphered that emotions acted as differential carriers of misinformation across geography and time. These carriers can be monitored to develop strategic interventions for countering misinformation, leading to improved public health.