Wireless communication in millimetre wave bands, namely above 20 GHz and up to 300 GHz, is foreseen as a key enabler technology for the next generation of wireless systems. The huge available bandwidth is contemplated to achieve high data-rate wireless communications, and hence, to fulfil the requirements of future wireless networks. In this paper, we discuss and illustrate new paradigms for the sub-THz physical layer, which either aim at maximizing the spectral efficiency, minimizing the device complexity, or finding good tradeoff. The solutions offered by appropriate modulation schemes and multi-antenna systems are assessed based on various potential scenarios.