Pan-sharpening algorithm utilizes panchromatic image and multispectral image to obtain a high spatial and high spectral image. However, the optimizations of the algorithms are designed with different standards. We adopt the simple matrix equation to describe the Pan-sharpening problem. The solution existence condition and the acquirement of spectral and spatial resolution are discussed. A down-sampling enhancement method was introduced for better acquiring the spatial and spectral down-sample matrices. By the generalized inverse theory, we derived two forms of general inverse matrix formulations that can correspond to the two prominent classes of Pan-sharpening methods, that is, component substitution and multi-resolution analysis methods. Specifically, the Gram Schmidt Adaptive(GSA) was proved to follow the general inverse matrix formulation of component substitution. A model prior to the general inverse matrix of the spectral function was rendered. The theoretical errors are analyzed. Synthetic experiments and real data experiments are implemented. The proposed methods are better and sharper than other methods qualitatively in both synthetic and real experiments. The down-sample enhancement effect is shown of better results both quantitatively and qualitatively in real experiments. The generalized inverse matrix theory help us better understand the Pan-sharpening.