We explore many ways of using conceptual distance measures in Word Sense Disambiguation, starting with the Agirre-Rigau conceptual density measure. We use a generalized form of this measure, introducing many (parameterized) refinements and performing an exhaustive evaluation of all meaningful combinations. We finally obtain a 42% improvement over the original algorithm, and show that measures of conceptual distance are not worse indicators for sense disambiguation than measures based on word-coocurrence (exemplified by the Lesk algorithm). Our results, however, reinforce the idea that only a combination of different sources of knowledge might eventually lead to accurate word sense disambiguation.