In this paper, we consider the problem of improving the inference latency of language model-based dense retrieval systems by introducing structural compression and model size asymmetry between the context and query encoders. First, we investigate the impact of pre and post-training compression on the MSMARCO, Natural Questions, TriviaQA, SQUAD, and SCIFACT, finding that asymmetry in the dual encoders in dense retrieval can lead to improved inference efficiency. Knowing this, we introduce Kullback Leibler Alignment of Embeddings (KALE), an efficient and accurate method for increasing the inference efficiency of dense retrieval methods by pruning and aligning the query encoder after training. Specifically, KALE extends traditional Knowledge Distillation after bi-encoder training, allowing for effective query encoder compression without full retraining or index generation. Using KALE and asymmetric training, we can generate models which exceed the performance of DistilBERT despite having 3x faster inference.