In this work we introduce a structured signaling game, an extension of the classical signaling game with a similarity structure between meanings in the context, along with a variant of the Rational Speech Act (RSA) framework which we call structured-RSA (sRSA) for pragmatic reasoning in structured domains. We explore the behavior of the sRSA in the domain of color and show that pragmatic agents using sRSA on top of semantic representations, derived from the World Color Survey, attain efficiency very close to the information theoretic limit after only 1 or 2 levels of recursion. We also explore the interaction between pragmatic reasoning and learning in multi-agent reinforcement learning framework. Our results illustrate that artificial agents using sRSA develop communication closer to the information theoretic frontier compared to agents using RSA and just reinforcement learning. We also find that the ambiguity of the semantic representation increases as the pragmatic agents are allowed to perform deeper reasoning about each other during learning.