Machine learning methods usually rely on large sample size to have good performance, while it is difficult to provide labeled set in many applications. Pool-based active learning methods are there to detect, among a set of unlabeled data, the ones that are the most relevant for the training. We propose in this paper a meta-approach for pool-based active learning strategies in the context of multi-class classification tasks based on Proper Topological Regions. PTR, based on topological data analysis (TDA), are relevant regions used to sample cold-start points or within the active learning scheme. The proposed method is illustrated empirically on various benchmark datasets, being competitive to the classical methods from the literature.