Recently, the application of Contrastive Representation Learning (CRL) in learning with noisy labels (LNL) has shown promising advancements due to its remarkable ability to learn well-distributed representations for better distinguishing noisy labels. However, CRL is mainly used as a pre-training technique, leading to a complicated multi-stage training pipeline. We also observed that trivially combining CRL with supervised LNL methods decreases performance. Using different images from the same class as negative pairs in CRL creates optimization conflicts between CRL and the supervised loss. To address these two issues, we propose an end-to-end PLReMix framework that avoids the complicated pipeline by introducing a Pseudo-Label Relaxed (PLR) contrastive loss to alleviate the conflicts between losses. This PLR loss constructs a reliable negative set of each sample by filtering out its inappropriate negative pairs that overlap at the top k indices of prediction probabilities, leading to more compact semantic clusters than vanilla CRL. Furthermore, a two-dimensional Gaussian Mixture Model (GMM) is adopted to distinguish clean and noisy samples by leveraging semantic information and model outputs simultaneously, which is expanded on the previously widely used one-dimensional form. The PLR loss and a semi-supervised loss are simultaneously applied to train on the GMM divided clean and noisy samples. Experiments on multiple benchmark datasets demonstrate the effectiveness of the proposed method. Our proposed PLR loss is scalable, which can be easily integrated into other LNL methods and boost their performance. Codes will be available.