In many scenarios, the communication system suffers from both Gaussian white noise and non-Gaussian impulsive noise. In order to design optimal signal detection method, it is necessary to estimate the parameters of mixed Gaussian-impulsive noise. Even though this issue can be well tackled with respect to pure mixed noise, it is quite challenging based on the received single-channel signal including both transmitting signal and mixed noise. To mitigate the negative impact of transmitting signal, we propose a parameter estimation method by utilizing a neural network, namely U-net++, to separate the mixed noise from the received single-channel signal. Compared with existing blind source separation based methods, simulation results show that our proposed method can obtain rather better performance in terms of estimation accuracy and robustness under various scenarios.