A primary goal in strategic classification is to learn decision rules which are robust to strategic input manipulation. Earlier works assume that strategic responses are known; while some recent works address the important challenge of unknown responses, they exclusively study sequential settings which allow multiple model deployments over time. But there are many domains$\unicode{x2014}$particularly in public policy, a common motivating use-case$\unicode{x2014}$where multiple deployments are unrealistic, or where even a single bad round is undesirable. To address this gap, we initiate the study of strategic classification under unknown responses in the one-shot setting, which requires committing to a single classifier once. Focusing on the users' cost function as the source of uncertainty, we begin by proving that for a broad class of costs, even a small mis-estimation of the true cost can entail arbitrarily low accuracy in the worst case. In light of this, we frame the one-shot task as a minimax problem, with the goal of identifying the classifier with the smallest worst-case risk over an uncertainty set of possible costs. Our main contribution is efficient algorithms for both the full-batch and stochastic settings, which we prove converge (offline) to the minimax optimal solution at the dimension-independent rate of $\tilde{\mathcal{O}}(T^{-\frac{1}{2}})$. Our analysis reveals important structure stemming from the strategic nature of user responses, particularly the importance of dual norm regularization with respect to the cost function.