Scene sketching is to convert a scene into a simplified, abstract representation that captures the essential elements and composition of the original scene. It requires semantic understanding of the scene and consideration of different regions within the scene. Since scenes often contain diverse visual information across various regions, such as foreground objects, background elements, and spatial divisions, dealing with these different regions poses unique difficulties. In this paper, we define a sketch as some sets of Bezier curves. We optimize the different regions of input scene in multiple rounds. In each round of optimization, strokes sampled from the next region can seamlessly be integrated into the sketch generated in the previous round of optimization. We propose additional stroke initialization method to ensure the integrity of the scene and the convergence of optimization. A novel CLIP-Based Semantic loss and a VGG-Based Feature loss are utilized to guide our multi-round optimization. Extensive experimental results on the quality and quantity of the generated sketches confirm the effectiveness of our method.