Intelligent machines (IMs), including industrial machines, unmanned aerial vehicles (UAVs), and unmanned vehicles, etc., could perform effective cooperation in complex environment when they form IM network. The efficient environment sensing and communication are crucial for IM network, enabling the real-time and stable control of IMs. With the emergence of integrated sensing and communication (ISAC) technology, IM network is empowered with ubiquitous sensing capabilities, which is helpful in improving the efficiency of communication and sensing with the mutual benefit of them. However, the massive amount of sensing information brings challenges for the processing, storage and application of sensing information. In this article, ISAC driven digital twin (DT) is proposed for IM network, and the architecture and enabling technologies are revealed. ISAC driven DT structurally stores the sensing information, which is further applied to optimize communication, networking and control schemes of IMs, promoting the widespread applications of IMs.