We present new algorithms for inference in credal networks --- directed acyclic graphs associated with sets of probabilities. Credal networks are here interpreted as encoding strong independence relations among variables. We first present a theory of credal networks based on separately specified sets of probabilities. We also show that inference with polytrees is NP-hard in this setting. We then introduce new techniques that reduce the computational effort demanded by inference, particularly in polytrees, by exploring separability of credal sets.