Heat, Ventilation and Air Conditioning (HVAC) systems play a critical role in maintaining a comfortable thermal environment and cost approximately 40% of primary energy usage in the building sector. For smart energy management in buildings, usage patterns and their resulting profiles allow the improvement of control systems with prediction capabilities. However, for large-scale HVAC system management, it is difficult to construct a detailed model for each subsystem. In this paper, a new data-driven room temperature prediction model is proposed based on the k-means clustering method. The proposed data-driven temperature prediction approach extracts the system operation feature through historical data analysis and further simplifies the system-level model to improve generalization and computational efficiency. We evaluate the proposed approach in the real world. The results demonstrated that our approach can significantly reduce modeling time without reducing prediction accuracy.