Several parameter-efficient fine-tuning methods based on adapters have been proposed as a streamlined approach to incorporate not only a single specialized knowledge into existing Pre-Trained Language Models (PLMs) but also multiple of them at once. Recent works such as AdapterSoup propose to mix not all but only a selective sub-set of domain-specific adapters during inference via model weight averaging to optimize performance on novel, unseen domains with excellent computational efficiency. However, the essential generalizability of this emerging weight-space adapter mixing mechanism on unseen, in-domain examples remains unexplored. Thus, in this study, we conduct a comprehensive analysis to elucidate the generalizability of domain-specific adapter mixtures in in-domain evaluation. We also provide investigations into the inner workings of the mixture of domain-specific adapters by analyzing their weight signs, yielding critical analysis on the negative correlation between their fraction of weight sign difference and their mixtures' generalizability. All source code will be published.