Few-shot Learning Based on Multi-stage Transfer and Class-Balanced Loss for Diabetic Retinopathy Grading

Diabetic retinopathy (DR) is one of the major blindness-causing diseases current-ly known. Automatic grading of DR using deep learning methods not only speeds up the diagnosis of the disease but also reduces the rate of misdiagnosis. However, problems such as insufficient samples and imbalanced class distribu-tion in DR datasets have constrained the improvement of grading performance. In this paper, we introduce the idea of multi-stage transfer into the grading task of DR. The new transfer learning technique leverages multiple datasets with differ-ent scales to enable the model to learn more feature representation information. Meanwhile, to cope with imbalanced DR datasets, we present a class-balanced loss function that performs well in natural image classification tasks, and adopt a simple and easy-to-implement training method for it. The experimental results show that the application of multi-stage transfer and class-balanced loss function can effectively improve the grading performance metrics such as accuracy and quadratic weighted kappa. In fact, our method has outperformed two state-of-the-art methods and achieved the best result on the DR grading task of IDRiD Sub-Challenge 2.