We investigate Early Hybrid Automatic Repeat reQuest (E-HARQ) feedback schemes enhanced by Machine Learning techniques as possible path towards ultra-reliable and low-latency communication (URLLC). To this end we propose Machine Learning methods to predict the outcome of the decoding process ahead of the end of the transmission. We discuss different input features and classification algorithms ranging from traditional methods to newly developed supervised autoencoders and their prospects of reaching effective block error rates of $10^{-5}$ that are required for URLLC with only small latency overhead. We provide realistic performance estimates in a system model incorporating scheduling effects to demonstrate the feasibility of E-HARQ across different signal-to-noise ratios, subcode lengths, channel conditions and system loads.