An iris presentation attack detection (IPAD) is essential for securing personal identity is widely used iris recognition systems. However, the existing IPAD algorithms do not generalize well to unseen and cross-domain scenarios because of capture in unconstrained environments and high visual correlation amongst bonafide and attack samples. These similarities in intricate textural and morphological patterns of iris ocular images contribute further to performance degradation. To alleviate these shortcomings, this paper proposes DFCANet: Dense Feature Calibration and Attention Guided Network which calibrates the locally spread iris patterns with the globally located ones. Uplifting advantages from feature calibration convolution and residual learning, DFCANet generates domain-specific iris feature representations. Since some channels in the calibrated feature maps contain more prominent information, we capitalize discriminative feature learning across the channels through the channel attention mechanism. In order to intensify the challenge for our proposed model, we make DFCANet operate over nonsegmented and non-normalized ocular iris images. Extensive experimentation conducted over challenging cross-domain and intra-domain scenarios highlights consistent outperforming results. Compared to state-of-the-art methods, DFCANet achieves significant gains in performance for the benchmark IIITD CLI, IIIT CSD and NDCLD13 databases respectively. Further, a novel incremental learning-based methodology has been introduced so as to overcome disentangled iris-data characteristics and data scarcity. This paper also pursues the challenging scenario that considers soft-lens under the attack category with evaluation performed under various cross-domain protocols. The code will be made publicly available.