We address the problem of people detection in RGB-D data where we leverage depth information to develop a region-of-interest (ROI) selection method that provides proposals to two color and depth CNNs. To combine the detections produced by the two CNNs, we propose a novel fusion approach based on the characteristics of depth images. We also present a new depth-encoding scheme, which not only encodes depth images into three channels but also enhances the information for classification. We conduct experiments on a publicly available RGB-D people dataset and show that our approach outperforms the baseline models that only use RGB data.