The Kolmogorov-Smirnov (KS) test is popularly used in many applications, such as anomaly detection, astronomy, database security and AI systems. One challenge remained untouched is how we can obtain an interpretation on why a test set fails the KS test. In this paper, we tackle the problem of producing counterfactual interpretations for test data failing the KS test. Concept-wise, we propose the notion of most comprehensible counterfactual interpretations, which accommodates both the KS test data and the user domain knowledge in producing interpretations. Computation-wise, we develop an efficient algorithm MOCHI that avoids enumerating and checking an exponential number of subsets of the test set failing the KS test. MOCHI not only guarantees to produce the most comprehensible counterfactual interpretations, but also is orders of magnitudes faster than the baselines. Experiment-wise, we present a systematic empirical study on a series of benchmark real datasets to verify the effectiveness, efficiency and scalability of most comprehensible counterfactual interpretations and MOCHI.