We present a novel way to perform image registration, which is not limited to a specific kind, between image pairs with very large deformation, while preserving Quasiconformal property without tedious manual landmark labeling that conventional mathematical registration methods require. Alongside the practical function of our algorithm, one just-as-important underlying message is that the integration between typical CNN and existing Mathematical model is successful as will be pointed out by our paper, meaning that machine learning and mathematical model could coexist, cover for each other and significantly improve registration result. This paper will demonstrate an unprecedented idea of making use of both robustness of CNNs and rigorousness of mathematical model to obtain meaningful registration maps between 2D images under the aforementioned strict constraints for the sake of well-posedness.