Hyperparameter optimization is very frequently employed in machine learning. However, an optimization of a large space of parameters could result in overfitting of models. In recent studies on solubility prediction the authors collected seven thermodynamic and kinetic solubility datasets from different data sources. They used state-of-the-art graph-based methods and compared models developed for each dataset using different data cleaning protocols and hyperparameter optimization. In our study we showed that hyperparameter optimization did not always result in better models, possibly due to overfitting when using the same statistical measures. Similar results could be calculated using pre-set hyperparameters, reducing the computational effort by around 10,000 times. We also extended the previous analysis by adding a representation learning method based on Natural Language Processing of smiles called Transformer CNN. We show that across all analyzed sets using exactly the same protocol, Transformer CNN provided better results than graph-based methods for 26 out of 28 pairwise comparisons by using only a tiny fraction of time as compared to other methods. Last but not least we stressed the importance of comparing calculation results using exactly the same statistical measures.