Image information is restricted by the dynamic range of the detector, which can be addressed using multi-exposure image fusion (MEF). The conventional MEF approach employed in ptychography is often inadequate under conditions of low signal-to-noise ratio (SNR) or variations in illumination intensity. To address this, we developed a Bayesian approach for MEF based on a modified Poisson noise model that considers the background and saturation. Our method outperforms conventional MEF under challenging experimental conditions, as demonstrated by the synthetic and experimental data. Furthermore, this method is versatile and applicable to any imaging scheme requiring high dynamic range (HDR).