Digital transformation often entails small-scale changes to information systems supporting the execution of business processes. These changes may increase the operational frictions in process execution, which decreases the process performance. The contributions in the literature providing support to the tracking and impact analysis of small-scale changes are limited in scope and functionality. In this paper, we use the recently developed Digital Twins of Organizations (DTOs) to assess the impact of (process-aware) information systems updates. More in detail, we model the updates using the configuration of DTOs and quantitatively assess different types of impacts of information system updates (structural, operational, and performance-related). We implemented a prototype of the proposed approach. Moreover, we discuss a case study involving a standard ERP procure-to-pay business process.