For a regularized least squares estimation of discrete-valued signals, we propose an LiGME regularizer, as a nonconvex regularizer, of designated isolated minimizers. The proposed regularizer is designed as a Generalized Moreau Enhancement (GME) of the so-called SOAV convex regularizer. Every candidate vector in the discrete-valued set is aimed to be assigned to an isolated local minimizer of the proposed regularizer while the overall convexity of the regularized least squares model is maintained. Moreover, a global minimizer of the proposed model can be approximated iteratively by using a variant of cLiGME algorithm. To enhance the accuracy of the proposed estimation, we also propose a pair of simple modifications, called respectively an iterative reweighting and a generalized superiorization. Numerical experiments demonstrate the effectiveness of the proposed model and algorithms in a scenario of MIMO signal detection.