This paper studies the affine frequency division multiplexing (AFDM)-empowered sparse code multiple access (SCMA) system, referred to as AFDM-SCMA, for supporting massive connectivity in high-mobility environments. First, by placing the sparse codewords on the AFDM chirp subcarriers, the input-output (I/O) relation of AFDM-SCMA systems is presented. Next, we delve into the generalized receiver design, chirp rate selection, and error rate performance of the proposed AFDM-SCMA. The proposed AFDM-SCMA is shown to provide a general framework and subsume the existing OFDM-SCMA as a special case. Third, for efficient transceiver design, we further propose a class of sparse codebooks for simplifying the I/O relation, referred to as I/O relation-inspired codebook design in this paper. Building upon these codebooks, we propose a novel iterative detection and decoding scheme with linear minimum mean square error (LMMSE) estimator for both downlink and uplink channels based on orthogonal approximate message passing principles. Our numerical results demonstrate the superiority of the proposed AFDM-SCMA systems over OFDM-SCMA systems in terms of the error rate performance. We show that the proposed receiver can significantly enhance the error rate performance while reducing the detection complexity.