This paper addresses the challenge of developing a robust audio-visual deepfake detection model. In practical use cases, new generation algorithms are continually emerging, and these algorithms are not encountered during the development of detection methods. This calls for the generalization ability of the method. Additionally, to ensure the credibility of detection methods, it is beneficial for the model to interpret which cues from the video indicate it is fake. Motivated by these considerations, we then propose a multi-stream fusion approach with one-class learning as a representation-level regularization technique. We study the generalization problem of audio-visual deepfake detection by creating a new benchmark by extending and re-splitting the existing FakeAVCeleb dataset. The benchmark contains four categories of fake video(Real Audio-Fake Visual, Fake Audio-Fake Visual, Fake Audio-Real Visual, and unsynchronized video). The experimental results show that our approach improves the model's detection of unseen attacks by an average of 7.31% across four test sets, compared to the baseline model. Additionally, our proposed framework offers interpretability, indicating which modality the model identifies as fake.