Despite accuracy and computation benchmarks being widely available to help choose among neural network models, these are usually trained on datasets with many classes, and do not give a precise idea of performance for applications of few (< 10) classes. The conventional procedure to predict performance is to train and test repeatedly on the different models and dataset variations of interest. However, this is computationally expensive. We propose an efficient classification difficulty measure that is calculated from the number of classes and intra- and inter-class similarity metrics of the dataset. After a single stage of training and testing per model family, relative performance for different datasets and models of the same family can be predicted by comparing difficulty measures - without further training and testing. We show how this measure can help a practitioner select a computationally efficient model for a small dataset 6 to 29x faster than through repeated training and testing. We give an example of use of the measure for an industrial application in which options are identified to select a model 42% smaller than the baseline YOLOv5-nano model, and if class merging from 3 to 2 classes meets requirements, 85% smaller.