Cardiovascular Disease Detection By Leveraging Semi-Supervised Learning

Cardiovascular disease (CVD) persists as a primary cause of death on a global scale, which requires more effective and timely detection methods. Traditional supervised learning approaches for CVD detection rely heavily on large-labeled datasets, which are often difficult to obtain. This paper employs semi-supervised learning models to boost efficiency and accuracy of CVD detection when there are few labeled samples. By leveraging both labeled and vast amounts of unlabeled data, our approach demonstrates improvements in prediction performance, while reducing the dependency on labeled data. Experimental results in a publicly available dataset show that semi-supervised models outperform traditional supervised learning techniques, providing an intriguing approach for the initial identification of cardiovascular disease within clinical environments.

Graphical Structural Learning of rs-fMRI data in Heavy Smokers

Recent studies revealed structural and functional brain changes in heavy smokers. However, the specific changes in topological brain connections are not well understood. We used Gaussian Undirected Graphs with the graphical lasso algorithm on rs-fMRI data from smokers and non-smokers to identify significant changes in brain connections. Our results indicate high stability in the estimated graphs and identify several brain regions significantly affected by smoking, providing valuable insights for future clinical research.

Identification of Prognostic Biomarkers for Stage III Non-Small Cell Lung Carcinoma in Female Nonsmokers Using Machine Learning

Lung cancer remains a leading cause of cancer-related deaths globally, with non-small cell lung cancer (NSCLC) being the most common subtype. This study aimed to identify key biomarkers associated with stage III NSCLC in non-smoking females using gene expression profiling from the GDS3837 dataset. Utilizing XGBoost, a machine learning algorithm, the analysis achieved a strong predictive performance with an AUC score of 0.835. The top biomarkers identified - CCAAT enhancer binding protein alpha (C/EBP-alpha), lactate dehydrogenase A4 (LDHA), UNC-45 myosin chaperone B (UNC-45B), checkpoint kinase 1 (CHK1), and hypoxia-inducible factor 1 subunit alpha (HIF-1-alpha) - have been validated in the literature as being significantly linked to lung cancer. These findings highlight the potential of these biomarkers for early diagnosis and personalized therapy, emphasizing the value of integrating machine learning with molecular profiling in cancer research.