FgC2F-UDiff: Frequency-guided and Coarse-to-fine Unified Diffusion Model for Multi-modality Missing MRI Synthesis

Multi-modality magnetic resonance imaging (MRI) is essential for the diagnosis and treatment of brain tumors. However, missing modalities are commonly observed due to limitations in scan time, scan corruption, artifacts, motion, and contrast agent intolerance. Synthesis of missing MRI has been a means to address the limitations of modality insufficiency in clinical practice and research. However, there are still some challenges, such as poor generalization, inaccurate non-linear mapping, and slow processing speeds. To address the aforementioned issues, we propose a novel unified synthesis model, the Frequency-guided and Coarse-to-fine Unified Diffusion Model (FgC2F-UDiff), designed for multiple inputs and outputs. Specifically, the Coarse-to-fine Unified Network (CUN) fully exploits the iterative denoising properties of diffusion models, from global to detail, by dividing the denoising process into two stages, coarse and fine, to enhance the fidelity of synthesized images. Secondly, the Frequency-guided Collaborative Strategy (FCS) harnesses appropriate frequency information as prior knowledge to guide the learning of a unified, highly non-linear mapping. Thirdly, the Specific-acceleration Hybrid Mechanism (SHM) integrates specific mechanisms to accelerate the diffusion model and enhance the feasibility of many-to-many synthesis. Extensive experimental evaluations have demonstrated that our proposed FgC2F-UDiff model achieves superior performance on two datasets, validated through a comprehensive assessment that includes both qualitative observations and quantitative metrics, such as PSNR SSIM, LPIPS, and FID.

Predicting Mitral Valve mTEER Surgery Outcomes Using Machine Learning and Deep Learning Techniques

Mitral Transcatheter Edge-to-Edge Repair (mTEER) is a medical procedure utilized for the treatment of mitral valve disorders. However, predicting the outcome of the procedure poses a significant challenge. This paper makes the first attempt to harness classical machine learning (ML) and deep learning (DL) techniques for predicting mitral valve mTEER surgery outcomes. To achieve this, we compiled a dataset from 467 patients, encompassing labeled echocardiogram videos and patient reports containing Transesophageal Echocardiography (TEE) measurements detailing Mitral Valve Repair (MVR) treatment outcomes. Leveraging this dataset, we conducted a benchmark evaluation of six ML algorithms and two DL models. The results underscore the potential of ML and DL in predicting mTEER surgery outcomes, providing insight for future investigation and advancements in this domain.

Edge-aware Multi-task Network for Integrating Quantification Segmentation and Uncertainty Prediction of Liver Tumor on Multi-modality Non-contrast MRI

Simultaneous multi-index quantification, segmentation, and uncertainty estimation of liver tumors on multi-modality non-contrast magnetic resonance imaging (NCMRI) are crucial for accurate diagnosis. However, existing methods lack an effective mechanism for multi-modality NCMRI fusion and accurate boundary information capture, making these tasks challenging. To address these issues, this paper proposes a unified framework, namely edge-aware multi-task network (EaMtNet), to associate multi-index quantification, segmentation, and uncertainty of liver tumors on the multi-modality NCMRI. The EaMtNet employs two parallel CNN encoders and the Sobel filters to extract local features and edge maps, respectively. The newly designed edge-aware feature aggregation module (EaFA) is used for feature fusion and selection, making the network edge-aware by capturing long-range dependency between feature and edge maps. Multi-tasking leverages prediction discrepancy to estimate uncertainty and improve segmentation and quantification performance. Extensive experiments are performed on multi-modality NCMRI with 250 clinical subjects. The proposed model outperforms the state-of-the-art by a large margin, achieving a dice similarity coefficient of 90.01$\pm$1.23 and a mean absolute error of 2.72$\pm$0.58 mm for MD. The results demonstrate the potential of EaMtNet as a reliable clinical-aided tool for medical image analysis.