Abstract:Navigating complex environments requires Unmanned Aerial Vehicles (UAVs) and autonomous systems to perform trajectory tracking and obstacle avoidance in real-time. While many control strategies have effectively utilized linear approximations, addressing the non-linear dynamics of UAV, especially in obstacle-dense environments, remains a key challenge that requires further research. This paper introduces a Non-linear Model Predictive Control (NMPC) framework for the DJI Matrice 100, addressing these challenges by using a dynamic model and B-spline interpolation for smooth reference trajectories, ensuring minimal deviation while respecting safety constraints. The framework supports various trajectory types and employs a penalty-based cost function for control accuracy in tight maneuvers. The framework utilizes CasADi for efficient real-time optimization, enabling the UAV to maintain robust operation even under tight computational constraints. Simulation and real-world indoor and outdoor experiments demonstrated the NMPC ability to adapt to disturbances, resulting in smooth, collision-free navigation.