Framework for developing and evaluating ethical collaboration between expert and machine

Precision medicine is a promising approach for accessible disease diagnosis and personalized intervention planning in high-mortality diseases such as coronary artery disease (CAD), drug-resistant epilepsy (DRE), and chronic illnesses like Type 1 diabetes (T1D). By leveraging artificial intelligence (AI), precision medicine tailors diagnosis and treatment solutions to individual patients by explicitly modeling variance in pathophysiology. However, the adoption of AI in medical applications faces significant challenges, including poor generalizability across centers, demographics, and comorbidities, limited explainability in clinical terms, and a lack of trust in ethical decision-making. This paper proposes a framework to develop and ethically evaluate expert-guided multi-modal AI, addressing these challenges in AI integration within precision medicine. We illustrate this framework with case study on insulin management for T1D. To ensure ethical considerations and clinician engagement, we adopt a co-design approach where AI serves an assistive role, with final diagnoses or treatment plans emerging from collaboration between clinicians and AI.

Detection of Unknown-Unknowns in Cyber-Physical Systems using Statistical Conformance with Physics Guided Process Models

Unknown unknowns are operational scenarios in a cyber-physical system that are not accounted for in the design and test phase. As such under unknown-unknown scenarios, the operational behavior of the CPS is not guaranteed to meet requirements such as safety and efficacy specified using Signal Temporal Logic (STL) on the output trajectories. We propose a novel framework for analyzing the stochastic conformance of operational output characteristics of safety-critical cyber-physical systems that can discover unknown-unknown scenarios and evaluate potential safety hazards. We propose dynamics-induced hybrid recurrent neural networks (DiH-RNN) to mine a physics-guided surrogate model (PGSM) which is used to check the model conformance using STL on the model coefficients. We demonstrate the detection of operational changes in an Artificial Pancreas(AP) due to unknown insulin cartridge errors.