Modeling Feature Maps for Quantum Machine Learning

Quantum Machine Learning (QML) offers significant potential for complex tasks like genome sequence classification, but quantum noise on Noisy Intermediate-Scale Quantum (NISQ) devices poses practical challenges. This study systematically evaluates how various quantum noise models including dephasing, amplitude damping, depolarizing, thermal noise, bit-flip, and phase-flip affect key QML algorithms (QSVC, Peg-QSVC, QNN, VQC) and feature mapping techniques (ZFeatureMap, ZZFeatureMap, and PauliFeatureMap). Results indicate that QSVC is notably robust under noise, whereas Peg-QSVC and QNN are more sensitive, particularly to depolarizing and amplitude-damping noise. The PauliFeatureMap is especially vulnerable, highlighting difficulties in maintaining accurate classification under noisy conditions. These findings underscore the critical importance of feature map selection and noise mitigation strategies in optimizing QML for genomic classification, with promising implications for personalized medicine.

Modeling Quantum Machine Learning for Genomic Data Analysis

Quantum Machine Learning (QML) continues to evolve, unlocking new opportunities for diverse applications. In this study, we investigate and evaluate the applicability of QML models for binary classification of genome sequence data by employing various feature mapping techniques. We present an open-source, independent Qiskit-based implementation to conduct experiments on a benchmark genomic dataset. Our simulations reveal that the interplay between feature mapping techniques and QML algorithms significantly influences performance. Notably, the Pegasos Quantum Support Vector Classifier (Pegasos-QSVC) exhibits high sensitivity, particularly excelling in recall metrics, while Quantum Neural Networks (QNN) achieve the highest training accuracy across all feature maps. However, the pronounced variability in classifier performance, dependent on feature mapping, highlights the risk of overfitting to localized output distributions in certain scenarios. This work underscores the transformative potential of QML for genomic data classification while emphasizing the need for continued advancements to enhance the robustness and accuracy of these methodologies.

An Independent Implementation of Quantum Machine Learning Algorithms in Qiskit for Genomic Data

In this paper, we explore the power of Quantum Machine Learning as we extend, implement and evaluate algorithms like Quantum Support Vector Classifier (QSVC), Pegasos-QSVC, Variational Quantum Circuits (VQC), and Quantum Neural Networks (QNN) in Qiskit with diverse feature mapping techniques for genomic sequence classification.