Federated Causal Discovery Across Heterogeneous Datasets under Latent Confounding

Causal discovery across multiple datasets is often constrained by data privacy regulations and cross-site heterogeneity, limiting the use of conventional methods that require a single, centralized dataset. To address these challenges, we introduce fedCI, a federated conditional independence test that rigorously handles heterogeneous datasets with non-identical sets of variables, site-specific effects, and mixed variable types, including continuous, ordinal, binary, and categorical variables. At its core, fedCI uses a federated Iteratively Reweighted Least Squares (IRLS) procedure to estimate the parameters of generalized linear models underlying likelihood-ratio tests for conditional independence. Building on this, we develop fedCI-IOD, a federated extension of the Integration of Overlapping Datasets (IOD) algorithm, that replaces its meta-analysis strategy and enables, for the fist time, federated causal discovery under latent confounding across distributed and heterogeneous datasets. By aggregating evidence federatively, fedCI-IOD not only preserves privacy but also substantially enhances statistical power, achieving performance comparable to fully pooled analyses and mitigating artifacts from low local sample sizes. Our tools are publicly available as the fedCI Python package, a privacy-preserving R implementation of IOD, and a web application for the fedCI-IOD pipeline, providing versatile, user-friendly solutions for federated conditional independence testing and causal discovery.

exploreCOSMOS: Interactive Exploration of Conditional Statistical Shape Models in the Web-Browser

Statistical Shape Models of faces and various body parts are heavily used in medical image analysis, computer vision and visualization. Whilst the field is well explored with many existing tools, all of them aim at experts, which limits their applicability. We demonstrate the first tool that enables the convenient exploration of statistical shape models in the browser, with the capability to manipulate the faces in a targeted manner. This manipulation is performed via a posterior model given partial observations. We release our code and application on GitHub https://github.com/maximilian-hahn/exploreCOSMOS