A Three-Stage Algorithm for the Closest String Problem on Artificial and Real Gene Sequences

The Closest String Problem is an NP-hard problem that aims to find a string that has the minimum distance from all sequences that belong to the given set of strings. Its applications can be found in coding theory, computational biology, and designing degenerated primers, among others. There are efficient exact algorithms that have reached high-quality solutions for binary sequences. However, there is still room for improvement concerning the quality of solutions over DNA and protein sequences. In this paper, we introduce a three-stage algorithm that comprises the following process: first, we apply a novel alphabet pruning method to reduce the search space for effectively finding promising search regions. Second, a variant of beam search to find a heuristic solution is employed. This method utilizes a newly developed guiding function based on an expected distance heuristic score of partial solutions. Last, we introduce a local search to improve the quality of the solution obtained from the beam search. Furthermore, due to the lack of real-world benchmarks, two real-world datasets are introduced to verify the robustness of the method. The extensive experimental results show that the proposed method outperforms the previous approaches from the literature.

Graph Protection under Multiple Simultaneous Attacks: A Heuristic Approach

This work focuses on developing an effective meta-heuristic approach to protect against simultaneous attacks on nodes of a network modeled using a graph. Specifically, we focus on the $k$-strong Roman domination problem, a generalization of the well-known Roman domination problem on graphs. This general problem is about assigning integer weights to nodes that represent the number of field armies stationed at each node in order to satisfy the protection constraints while minimizing the total weights. These constraints concern the protection of a graph against any simultaneous attack consisting of $k \in \mathbb{N}$ nodes. An attack is considered repelled if each node labeled 0 can be defended by borrowing an army from one of its neighboring nodes, ensuring that the neighbor retains at least one army for self-defense. The $k$-SRD problem has practical applications in various areas, such as developing counter-terrorism strategies or managing supply chain disruptions. The solution to this problem is notoriously difficult to find, as even checking the feasibility of the proposed solution requires an exponential number of steps. We propose a variable neighborhood search algorithm in which the feasibility of the solution is checked by introducing the concept of quasi-feasibility, which is realized by careful sampling within the set of all possible attacks. Extensive experimental evaluations show the scalability and robustness of the proposed approach compared to the two exact approaches from the literature. Experiments are conducted with random networks from the literature and newly introduced random wireless networks as well as with real-world networks. A practical application scenario, using real-world networks, involves applying our approach to graphs extracted from GeoJSON files containing geographic features of hundreds of cities or larger regions.