Abstract:Language data and models demonstrate various types of bias, be it ethnic, religious, gender, or socioeconomic. AI/NLP models, when trained on the racially biased dataset, AI/NLP models instigate poor model explainability, influence user experience during decision making and thus further magnifies societal biases, raising profound ethical implications for society. The motivation of the study is to investigate how AI systems imbibe bias from data and produce unexplainable discriminatory outcomes and influence an individual's articulateness of system outcome due to the presence of racial bias features in datasets. The design of the experiment involves studying the counterfactual impact of racial bias features present in language datasets and its associated effect on the model outcome. A mixed research methodology is adopted to investigate the cross implication of biased model outcome on user experience, effect on decision-making through controlled lab experimentation. The findings provide foundation support for correlating the implication of carry-over an artificial intelligence model solving NLP task due to biased concept presented in the dataset. Further, the research outcomes justify the negative influence on users' persuasiveness that leads to alter the decision-making quotient of an individual when trying to rely on the model outcome to act. The paper bridges the gap across the harm caused in establishing poor customer trustworthiness due to an inequitable system design and provides strong support for researchers, policymakers, and data scientists to build responsible AI frameworks within organizations.
Abstract:Patient-derived extracellular vesicles (EVs) that contains a complex biological cargo is a valuable source of liquid biopsy diagnostics to aid in early detection, cancer screening, and precision nanotherapeutics. In this study, we predicted that coupling cancer patient blood-derived EVs to time-resolved spectroscopy and artificial intelligence (AI) could provide a robust cancer screening and follow-up tools. Methods: Fluorescence correlation spectroscopy (FCS) measurements were performed on 24 blood samples-derived EVs. Blood samples were obtained from 15 cancer patients (presenting 5 different types of cancers), and 9 healthy controls (including patients with benign lesions). The obtained FCS autocorrelation spectra were processed into power spectra using the Fast-Fourier Transform algorithm and subjected to various machine learning algorithms to distinguish cancer spectra from healthy control spectra. Results and Applications: The performance of AdaBoost Random Forest (RF) classifier, support vector machine, and multilayer perceptron, were tested on selected frequencies in the N=118 power spectra. The RF classifier exhibited a 90% classification accuracy and high sensitivity and specificity in distinguishing the FCS power spectra of cancer patients from those of healthy controls. Further, an image convolutional neural network (CNN), ResNet network, and a quantum CNN were assessed on the power spectral images as additional validation tools. All image-based CNNs exhibited a nearly equal classification performance with an accuracy of roughly 82% and reasonably high sensitivity and specificity scores. Our pilot study demonstrates that AI-algorithms coupled to time-resolved FCS power spectra can accurately and differentially classify the complex patient-derived EVs from different cancer samples of distinct tissue subtypes.
Abstract:The purpose of the paper is to provide innovative emerging technology framework for community to combat epidemic situations. The paper proposes a unique outbreak response system framework based on artificial intelligence and edge computing for citizen centric services to help track and trace people eluding safety policies like mask detection and social distancing measure in public or workplace setup. The framework further provides implementation guideline in industrial setup as well for governance and contact tracing tasks. The adoption will thus lead in smart city planning and development focusing on citizen health systems contributing to improved quality of life. The conceptual framework presented is validated through quantitative data analysis via secondary data collection from researcher's public websites, GitHub repositories and renowned journals and further benchmarking were conducted for experimental results in Microsoft Azure cloud environment. The study includes selective AI-models for benchmark analysis and were assessed on performance and accuracy in edge computing environment for large scale societal setup. Overall YOLO model Outperforms in object detection task and is faster enough for mask detection and HRNetV2 outperform semantic segmentation problem applied to solve social distancing task in AI-Edge inferencing environmental setup. The paper proposes new Edge-AI algorithm for building technology-oriented solutions for detecting mask in human movement and social distance. The paper enriches the technological advancement in artificial intelligence and edge-computing applied to problems in society and healthcare systems. The framework further equips government agency, system providers to design and constructs technology-oriented models in community setup to Increase the quality of life using emerging technologies into smart urban environments.