Entropy Bootstrapping for Weakly Supervised Nuclei Detection

Microscopy structure segmentation, such as detecting cells or nuclei, generally requires a human to draw a ground truth contour around each instance. Weakly supervised approaches (e.g. consisting of only single point labels) have the potential to reduce this workload significantly. Our approach uses individual point labels for an entropy estimation to approximate an underlying distribution of cell pixels. We infer full cell masks from this distribution, and use Mask-RCNN to produce an instance segmentation output. We compare this point--annotated approach with training on the full ground truth masks. We show that our method achieves a comparatively good level of performance, despite a 95% reduction in pixel labels.

Runtime Freezing: Dynamic Class Loss for Multi-Organ 3D Segmentation

Segmentation has become a crucial pre-processing step to many refined downstream tasks, and particularly so in the medical domain. Even with recent improvements in segmentation models, many segmentation tasks remain difficult. When multiple organs are segmented simultaneously, difficulties are due not only to the limited availability of labelled data, but also to class imbalance. In this work we propose dynamic class-based loss strategies to mitigate the effects of highly imbalanced training data. We show how our approach improves segmentation performance on a challenging Multi-Class 3D Abdominal Organ dataset.