OCTA-Based Biomarker Characterization in nAMD

We aim to enhance ophthalmologists' decision-making when diagnosing the Neovascular Age-Related Macular Degeneration (nAMD). We developed three tools to analyze Optical Coherence Tomography Angiography images: (1) extracting biomarkers such as mCNV area and vessel density using image processing; (2) generating a 3D visualization of the neovascularization for a better view of the affected regions; and (3) applying an ensemble of three white box machine learning algorithms (decision tree, support vector machines and DL-Learner) for nAMD diagnosis. The learned expressions reached 100% accuracy for the training data and 68% accuracy in testing. The main advantage is that all the learned models white-box, which ensures explainability and transparency, allowing clinicians to better understand the decision-making process.

Detecting diabetic retinopathy severity through fundus images using an ensemble of classifiers

Diabetic retinopathy is an ocular condition that affects individuals with diabetes mellitus. It is a common complication of diabetes that can impact the eyes and lead to vision loss. One method for diagnosing diabetic retinopathy is the examination of the fundus of the eye. An ophthalmologist examines the back part of the eye, including the retina, optic nerve, and the blood vessels that supply the retina. In the case of diabetic retinopathy, the blood vessels in the retina deteriorate and can lead to bleeding, swelling, and other changes that affect vision. We proposed a method for detecting diabetic diabetic severity levels. First, a set of data-prerpocessing is applied to available data: adaptive equalisation, color normalisation, Gaussian filter, removal of the optic disc and blood vessels. Second, we perform image segmentation for relevant markers and extract features from the fundus images. Third, we apply an ensemble of classifiers and we assess the trust in the system.