Abstract:1. Research question: With the growing interest in skin diseases and skin aesthetics, the ability to predict facial wrinkles is becoming increasingly important. This study aims to evaluate whether a computational model, convolutional neural networks (CNN), can be trained for automated facial wrinkle segmentation. 2. Findings: Our study presents an effective technique for integrating data from multiple annotators and illustrates that transfer learning can enhance performance, resulting in dependable segmentation of facial wrinkles. 3. Meaning: This approach automates intricate and time-consuming tasks of wrinkle analysis with a deep learning framework. It could be used to facilitate skin treatments and diagnostics.