Alzheimer's Disease Diagnostics by a Deeply Supervised Adaptable 3D Convolutional Network

Early diagnosis, playing an important role in preventing progress and treating the Alzheimer's disease (AD), is based on classification of features extracted from brain images. The features have to accurately capture main AD-related variations of anatomical brain structures, such as, e.g., ventricles size, hippocampus shape, cortical thickness, and brain volume. This paper proposes to predict the AD with a deep 3D convolutional neural network (3D-CNN), which can learn generic features capturing AD biomarkers and adapt to different domain datasets. The 3D-CNN is built upon a 3D convolutional autoencoder, which is pre-trained to capture anatomical shape variations in structural brain MRI scans. Fully connected upper layers of the 3D-CNN are then fine-tuned for each task-specific AD classification. Experiments on the \emph{ADNI} MRI dataset with no skull-stripping preprocessing have shown our 3D-CNN outperforms several conventional classifiers by accuracy and robustness. Abilities of the 3D-CNN to generalize the features learnt and adapt to other domains have been validated on the \emph{CADDementia} dataset.

Texture Modelling with Nested High-order Markov-Gibbs Random Fields

Currently, Markov-Gibbs random field (MGRF) image models which include high-order interactions are almost always built by modelling responses of a stack of local linear filters. Actual interaction structure is specified implicitly by the filter coefficients. In contrast, we learn an explicit high-order MGRF structure by considering the learning process in terms of general exponential family distributions nested over base models, so that potentials added later can build on previous ones. We relatively rapidly add new features by skipping over the costly optimisation of parameters. We introduce the use of local binary patterns as features in MGRF texture models, and generalise them by learning offsets to the surrounding pixels. These prove effective as high-order features, and are fast to compute. Several schemes for selecting high-order features by composition or search of a small subclass are compared. Additionally we present a simple modification of the maximum likelihood as a texture modelling-specific objective function which aims to improve generalisation by local windowing of statistics. The proposed method was experimentally evaluated by learning high-order MGRF models for a broad selection of complex textures and then performing texture synthesis, and succeeded on much of the continuum from stochastic through irregularly structured to near-regular textures. Learning interaction structure is very beneficial for textures with large-scale structure, although those with complex irregular structure still provide difficulties. The texture models were also quantitatively evaluated on two tasks and found to be competitive with other works: grading of synthesised textures by a panel of observers; and comparison against several recent MGRF models by evaluation on a constrained inpainting task.