Parkinson's Disease Diagnosis Through Deep Learning: A Novel LSTM-Based Approach for Freezing of Gait Detection

Deep learning holds tremendous potential in healthcare for uncovering hidden patterns within extensive clinical datasets, aiding in the diagnosis of various diseases. Parkinson's disease (PD) is a neurodegenerative condition characterized by the deterioration of brain function. In the initial stages of PD, automatic diagnosis poses a challenge due to the similarity in behavior between individuals with PD and those who are healthy. Our objective is to propose an effective model that can aid in the early detection of Parkinson's disease. We employed the VGRF gait signal dataset sourced from Physionet for distinguishing between healthy individuals and those diagnosed with Parkinson's disease. This paper introduces a novel deep learning architecture based on the LSTM network for automatically detecting freezing of gait episodes in Parkinson's disease patients. In contrast to conventional machine learning algorithms, this method eliminates manual feature engineering and proficiently captures prolonged temporal dependencies in gait patterns, thereby improving the diagnosis of Parkinson's disease. The LSTM network resolves the issue of vanishing gradients by employing memory blocks in place of self-connected hidden units, allowing for optimal information assimilation. To prevent overfitting, dropout and L2 regularization techniques have been employed. Additionally, the stochastic gradient-based optimizer Adam is used for the optimization process. The results indicate that our proposed approach surpasses current state-of-the-art models in FOG episode detection, achieving an accuracy of 97.71%, sensitivity of 99%, precision of 98%, and specificity of 96%. This demonstrates its potential as a superior classification method for Parkinson's disease detection.

MAPUNetR: A Hybrid Vision Transformer and U-Net Architecture for Efficient and Interpretable Medical Image Segmentation

Medical image segmentation is pivotal in healthcare, enhancing diagnostic accuracy, informing treatment strategies, and tracking disease progression. This process allows clinicians to extract critical information from visual data, enabling personalized patient care. However, developing neural networks for segmentation remains challenging, especially when preserving image resolution, which is essential in detecting subtle details that influence diagnoses. Moreover, the lack of transparency in these deep learning models has slowed their adoption in clinical practice. Efforts in model interpretability are increasingly focused on making these models' decision-making processes more transparent. In this paper, we introduce MAPUNetR, a novel architecture that synergizes the strengths of transformer models with the proven U-Net framework for medical image segmentation. Our model addresses the resolution preservation challenge and incorporates attention maps highlighting segmented regions, increasing accuracy and interpretability. Evaluated on the BraTS 2020 dataset, MAPUNetR achieved a dice score of 0.88 and a dice coefficient of 0.92 on the ISIC 2018 dataset. Our experiments show that the model maintains stable performance and potential as a powerful tool for medical image segmentation in clinical practice.