Abstract:"If I have seen further, it is by standing on the shoulders of giants," Isaac Newton's renowned statement hints that new knowledge builds upon existing foundations, which means there exists an interdependent relationship between knowledge, which, yet uncovered, is implied in the historical development of scientific systems for hundreds of years. By leveraging natural language processing techniques, this study introduces an innovative embedding scheme designed to infer the "knowledge interlocking map." This map, derived from the research trajectories of millions of scholars, reveals the intricate connections among knowledge. We validate that the inferred map effectively delineates disciplinary boundaries and captures the intricate relationships between diverse concepts. The utility of the interlocking map is showcased through multiple applications. Firstly, we demonstrated the multi-step analogy inferences within the knowledge space and the functional connectivity between concepts in different disciplines. Secondly, we trace the evolution of knowledge across domains, observing trends such as shifts from "Theoretical" to "Applied" or "Chemistry" to "Biomedical" along predefined functional directions. Lastly, by analyzing the high-dimensional knowledge network structure, we found that knowledge connects each other with shorter global pathways, and the interdisciplinary knowledge plays a critical role in accessibility of the global knowledge network. Our framework offers a novel approach to mining knowledge inheritance pathways in extensive scientific literature, which is of great significance for understanding scientific development patterns, tailoring scientific learning trajectories, and accelerating scientific progress.