Abstract:Artificial intelligence (AI) algorithms using deep learning have advanced the classification of skin disease images; however these algorithms have been mostly applied "in silico" and not validated clinically. Most dermatology AI algorithms perform binary classification tasks (e.g. malignancy versus benign lesions), but this task is not representative of dermatologists' diagnostic range. The American Academy of Dermatology Task Force on Augmented Intelligence published a position statement emphasizing the importance of clinical validation to create human-computer synergy, termed augmented intelligence (AuI). Liu et al's recent paper, "A deep learning system for differential diagnosis of skin diseases" represents a significant advancement of AI in dermatology, bringing it closer to clinical impact. However, significant issues must be addressed before this algorithm can be integrated into clinical workflow. These issues include accurate and equitable model development, defining and assessing appropriate clinical outcomes, and real-world integration.