Interactive Image Selection and Training for Brain Tumor Segmentation Network

Medical image segmentation is a relevant problem, with deep learning being an exponent. However, the necessity of a high volume of fully annotated images for training massive models can be a problem, especially for applications whose images present a great diversity, such as brain tumors, which can occur in different sizes and shapes. In contrast, a recent methodology, Feature Learning from Image Markers (FLIM), has involved an expert in the learning loop, producing small networks that require few images to train the convolutional layers. In this work, We employ an interactive method for image selection and training based on FLIM, exploring the user's knowledge. The results demonstrated that with our methodology, we could choose a small set of images to train the encoder of a U-shaped network, obtaining performance equal to manual selection and even surpassing the same U-shaped network trained with backpropagation and all training images.

Building Brain Tumor Segmentation Networks with User-Assisted Filter Estimation and Selection

Brain tumor image segmentation is a challenging research topic in which deep-learning models have presented the best results. However, the traditional way of training those models from many pre-annotated images leaves several unanswered questions. Hence methodologies, such as Feature Learning from Image Markers (FLIM), have involved an expert in the learning loop to reduce human effort in data annotation and build models sufficiently deep for a given problem. FLIM has been successfully used to create encoders, estimating the filters of all convolutional layers from patches centered at marker voxels. In this work, we present Multi-Step (MS) FLIM - a user-assisted approach to estimating and selecting the most relevant filters from multiple FLIM executions. MS-FLIM is used only for the first convolutional layer, and the results already indicate improvement over FLIM. For evaluation, we build a simple U-shaped encoder-decoder network, named sU-Net, for glioblastoma segmentation using T1Gd and FLAIR MRI scans, varying the encoder's training method, using FLIM, MS-FLIM, and backpropagation algorithm. Also, we compared these sU-Nets with two State-Of-The-Art (SOTA) deep-learning models using two datasets. The results show that the sU-Net based on MS-FLIM outperforms the other training methods and achieves effectiveness within the standard deviations of the SOTA models.