PSO-Net: Development of an automated psoriasis assessment system using attention-based interpretable deep neural networks

Psoriasis is a chronic skin condition that requires long-term treatment and monitoring. Although, the Psoriasis Area and Severity Index (PASI) is utilized as a standard measurement to assess psoriasis severity in clinical trials, it has many drawbacks such as (1) patient burden for in-person clinic visits for assessment of psoriasis, (2) time required for investigator scoring and (3) variability of inter- and intra-rater scoring. To address these drawbacks, we propose a novel and interpretable deep learning architecture called PSO-Net, which maps digital images from different anatomical regions to derive attention-based scores. Regional scores are further combined to estimate an absolute PASI score. Moreover, we devise a novel regression activation map for interpretability through ranking attention scores. Using this approach, we achieved inter-class correlation scores of 82.2% [95% CI: 77- 87%] and 87.8% [95% CI: 84-91%] with two different clinician raters, respectively.

Gaussian Harmony: Attaining Fairness in Diffusion-based Face Generation Models

Diffusion models have achieved great progress in face generation. However, these models amplify the bias in the generation process, leading to an imbalance in distribution of sensitive attributes such as age, gender and race. This paper proposes a novel solution to this problem by balancing the facial attributes of the generated images. We mitigate the bias by localizing the means of the facial attributes in the latent space of the diffusion model using Gaussian mixture models (GMM). Our motivation for choosing GMMs over other clustering frameworks comes from the flexible latent structure of diffusion model. Since each sampling step in diffusion models follows a Gaussian distribution, we show that fitting a GMM model helps us to localize the subspace responsible for generating a specific attribute. Furthermore, our method does not require retraining, we instead localize the subspace on-the-fly and mitigate the bias for generating a fair dataset. We evaluate our approach on multiple face attribute datasets to demonstrate the effectiveness of our approach. Our results demonstrate that our approach leads to a more fair data generation in terms of representational fairness while preserving the quality of generated samples.