TransformEEG: Towards Improving Model Generalizability in Deep Learning-based EEG Parkinson's Disease Detection

Electroencephalography (EEG) is establishing itself as an important, low-cost, noninvasive diagnostic tool for the early detection of Parkinson's Disease (PD). In this context, EEG-based Deep Learning (DL) models have shown promising results due to their ability to discover highly nonlinear patterns within the signal. However, current state-of-the-art DL models suffer from poor generalizability caused by high inter-subject variability. This high variability underscores the need for enhancing model generalizability by developing new architectures better tailored to EEG data. This paper introduces TransformEEG, a hybrid Convolutional-Transformer designed for Parkinson's disease detection using EEG data. Unlike transformer models based on the EEGNet structure, TransformEEG incorporates a depthwise convolutional tokenizer. This tokenizer is specialized in generating tokens composed by channel-specific features, which enables more effective feature mixing within the self-attention layers of the transformer encoder. To evaluate the proposed model, four public datasets comprising 290 subjects (140 PD patients, 150 healthy controls) were harmonized and aggregated. A 10-outer, 10-inner Nested-Leave-N-Subjects-Out (N-LNSO) cross-validation was performed to provide an unbiased comparison against seven other consolidated EEG deep learning models. TransformEEG achieved the highest balanced accuracy's median (78.45%) as well as the lowest interquartile range (6.37%) across all the N-LNSO partitions. When combined with data augmentation and threshold correction, median accuracy increased to 80.10%, with an interquartile range of 5.74%. In conclusion, TransformEEG produces more consistent and less skewed results. It demonstrates a substantial reduction in variability and more reliable PD detection using EEG data compared to the other investigated models.

The role of data partitioning on the performance of EEG-based deep learning models in supervised cross-subject analysis: a preliminary study

Deep learning is significantly advancing the analysis of electroencephalography (EEG) data by effectively discovering highly nonlinear patterns within the signals. Data partitioning and cross-validation are crucial for assessing model performance and ensuring study comparability, as they can produce varied results and data leakage due to specific signal properties (e.g., biometric). Such variability leads to incomparable studies and, increasingly, overestimated performance claims, which are detrimental to the field. Nevertheless, no comprehensive guidelines for proper data partitioning and cross-validation exist in the domain, nor is there a quantitative evaluation of their impact on model accuracy, reliability, and generalizability. To assist researchers in identifying optimal experimental strategies, this paper thoroughly investigates the role of data partitioning and cross-validation in evaluating EEG deep learning models. Five cross-validation settings are compared across three supervised cross-subject classification tasks (BCI, Parkinson's, and Alzheimer's disease detection) and four established architectures of increasing complexity (ShallowConvNet, EEGNet, DeepConvNet, and Temporal-based ResNet). The comparison of over 100,000 trained models underscores, first, the importance of using subject-based cross-validation strategies for evaluating EEG deep learning models, except when within-subject analyses are acceptable (e.g., BCI). Second, it highlights the greater reliability of nested approaches (N-LNSO) compared to non-nested counterparts, which are prone to data leakage and favor larger models overfitting to validation data. In conclusion, this work provides EEG deep learning researchers with an analysis of data partitioning and cross-validation and offers guidelines to avoid data leakage, currently undermining the domain with potentially overestimated performance claims.

xEEGNet: Towards Explainable AI in EEG Dementia Classification

This work presents xEEGNet, a novel, compact, and explainable neural network for EEG data analysis. It is fully interpretable and reduces overfitting through major parameter reduction. As an applicative use case, we focused on classifying common dementia conditions, Alzheimer's and frontotemporal dementia, versus controls. xEEGNet is broadly applicable to other neurological conditions involving spectral alterations. We initially used ShallowNet, a simple and popular model from the EEGNet-family. Its structure was analyzed and gradually modified to move from a "black box" to a more transparent model, without compromising performance. The learned kernels and weights were examined from a clinical standpoint to assess medical relevance. Model variants, including ShallowNet and the final xEEGNet, were evaluated using robust Nested-Leave-N-Subjects-Out cross-validation for unbiased performance estimates. Variability across data splits was explained using embedded EEG representations, grouped by class and set, with pairwise separability to quantify group distinction. Overfitting was assessed through training-validation loss correlation and training speed. xEEGNet uses only 168 parameters, 200 times fewer than ShallowNet, yet retains interpretability, resists overfitting, achieves comparable median performance (-1.5%), and reduces variability across splits. This variability is explained by embedded EEG representations: higher accuracy correlates with greater separation between test set controls and Alzheimer's cases, without significant influence from training data. xEEGNet's ability to filter specific EEG bands, learn band-specific topographies, and use relevant spectral features demonstrates its interpretability. While large deep learning models are often prioritized for performance, this study shows smaller architectures like xEEGNet can be equally effective in EEG pathology classification.

The more, the better? Evaluating the role of EEG preprocessing for deep learning applications

The last decade has witnessed a notable surge in deep learning applications for the analysis of electroencephalography (EEG) data, thanks to its demonstrated superiority over conventional statistical techniques. However, even deep learning models can underperform if trained with bad processed data. While preprocessing is essential to the analysis of EEG data, there is a need of research examining its precise impact on model performance. This causes uncertainty about whether and to what extent EEG data should be preprocessed in a deep learning scenario. This study aims at investigating the role of EEG preprocessing in deep learning applications, drafting guidelines for future research. It evaluates the impact of different levels of preprocessing, from raw and minimally filtered data to complex pipelines with automated artifact removal algorithms. Six classification tasks (eye blinking, motor imagery, Parkinson's and Alzheimer's disease, sleep deprivation, and first episode psychosis) and four different architectures commonly used in the EEG domain were considered for the evaluation. The analysis of 4800 different trainings revealed statistical differences between the preprocessing pipelines at the intra-task level, for each of the investigated models, and at the inter-task level, for the largest one. Raw data generally leads to underperforming models, always ranking last in averaged score. In addition, models seem to benefit more from minimal pipelines without artifact handling methods, suggesting that EEG artifacts may contribute to the performance of deep neural networks.

SelfEEG: A Python library for Self-Supervised Learning in Electroencephalography

SelfEEG is an open-source Python library developed to assist researchers in conducting Self-Supervised Learning (SSL) experiments on electroencephalography (EEG) data. Its primary objective is to offer a user-friendly but highly customizable environment, enabling users to efficiently design and execute self-supervised learning tasks on EEG data. SelfEEG covers all the stages of a typical SSL pipeline, ranging from data import to model design and training. It includes modules specifically designed to: split data at various granularity levels (e.g., session-, subject-, or dataset-based splits); effectively manage data stored with different configurations (e.g., file extensions, data types) during mini-batch construction; provide a wide range of standard deep learning models, data augmentations and SSL baseline methods applied to EEG data. Most of the functionalities offered by selfEEG can be executed both on GPUs and CPUs, expanding its usability beyond the self-supervised learning area. Additionally, these functionalities can be employed for the analysis of other biomedical signals often coupled with EEGs, such as electromyography or electrocardiography data. These features make selfEEG a versatile deep learning tool for biomedical applications and a useful resource in SSL, one of the currently most active fields of Artificial Intelligence.