Parameter-efficient fine-tuning methods (PEFTs) offer the promise of adapting large pre-trained models while only tuning a small number of parameters. They have been shown to be competitive with full model fine-tuning for many downstream tasks. However, prior work indicates that PEFTs may not work as well for machine translation (MT), and there is no comprehensive study showing when PEFTs work for MT. We conduct a comprehensive empirical study of PEFTs for MT, considering (1) various parameter budgets, (2) a diverse set of language-pairs, and (3) different pre-trained models. We find that 'adapters', in which small feed-forward networks are added after every layer, are indeed on par with full model fine-tuning when the parameter budget corresponds to 10% of total model parameters. Nevertheless, as the number of tuned parameters decreases, the performance of PEFTs decreases. The magnitude of this decrease depends on the language pair, with PEFTs particularly struggling for distantly related language-pairs. We find that using PEFTs with a larger pre-trained model outperforms full fine-tuning with a smaller model, and for smaller training data sizes, PEFTs outperform full fine-tuning for the same pre-trained model.